Deficiency of vitamin D is a general public health problems. The prevalence is increasing and becoming main problem today. It was found not only in woman and children, but also in pregnant mothers. Its happens because of lifestyle in the society, lack of sun exposure, low consumption of vitamin D, and adverse polymorphism vitamin D receptor (VDR) gene. Vitamin D status was associated with pregnancy outcomes and health status both of the maternal and fetal. Low vitamin D status was increasing the risk of preeclampsia in pregnant mothers. Vitamin D has an important role in the bone growth, regulating calcium and bone homeostasis, stimulating the transcription and non-genomic response, modulating the immune systems, and regulating proliferation and differentiation that is activated by 1,25-Dyhydroxy-vitamin D metabolism. Besides, it is associated with an increase degenerative disease in the child’s adulthood. Although this study still showing conflicting results for overall status vitamin D risks and preeclampsia, the function of vitamin D has been linked to pregnancy outcomes affected by preeclampsia incident. It is important to maintain the adequacy of vitamin D status in pregnant mothers.

We plan to study the effect of food consumption especially vitamin D consumption, lifestyle, and single nucleotide polymorphism of vitamin D receptor to the level of 25(OH) D serum levels and preeclampsia outcome. Also in an attempt to prevent the development of degenerative disease in the future and as government programs to improve the quality of public health through first 1000 days life nutrition programs that affect the quality and function of fetal development.

Keywords: Vitamin D, Single Nucleotide Polymorphism, Gene VDR, Lifestyle, Pregnancy